human NP shRNA silencing AAV

Cat. No: shAAV-216928

Availability: 4-5 weeks

Name: AAV-h-NP-shRNA

This is an AAV expressing shRNA for silencing of Human PNP.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PNP
Gene Name: purine nucleoside phosphorylase
Gene ID: 4860
Gene Synonyms: NP; PRO1837; PUNP
ORF Size: 870 bp
RefSeq#: NM_000270
Gene Description: PNP encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
UniGene ID: Hs.75514
HGNC ID: HGNC:7892