human GIT2 shRNA silencing AAV

Cat. No: shAAV-209910

Availability: 4-5 weeks

Name: AAV-h-GIT2-shRNA

This is an AAV expressing shRNA for silencing of Human GIT2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GIT2
Gene Name: GIT ArfGAP 2
Gene ID: 9815
Gene Synonyms: CAT-2; CAT2; PKL
ORF Size: 1416 bp
RefSeq#: NM_057169
Gene Description: GIT2 encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. GIT2 has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
UniGene ID: Hs.434996
HGNC ID: HGNC:4273