human ERCC8 shRNA silencing AAV

Cat. No: shAAV-210129

Availability: 4-5 weeks

Name: AAV-h-ERCC8-shRNA

This is an AAV expressing shRNA for silencing of Human ERCC8.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ERCC8
Gene Name: ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Gene ID: 1161
Gene Synonyms: CKN1; CSA; UVSS2
ORF Size: 618 bp
RefSeq#: NM_000082
Gene Description: ERCC8 encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
UniGene ID: Hs.435237
HGNC ID: HGNC:3439