human TTK shRNA silencing AAV

Cat. No: shAAV-226736

Availability: 4-5 weeks

Name: AAV-h-TTK-shRNA

This is an AAV expressing shRNA for silencing of Human TTK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TTK
Gene Name: TTK protein kinase
Gene ID: 7272
Gene Synonyms: CT96; ESK; MPH1; MPS1; MPS1L1; PYT
ORF Size: 2574 bp
RefSeq#: NM_003318
Gene Description: TTK encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.169840
HGNC ID: HGNC:12401