mouse MEMO1 shRNA silencing AAV

Cat. No: shAAV-264492

Availability: 4-5 weeks

Name: AAV-m-MEMO1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Memo1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Memo1
Gene Name: mediator of cell motility 1
Gene ID: 76890
Gene Synonyms: 0610016J10Rik; D930048L02Rik
ORF Size: 894 bp
RefSeq#: NM_133771
Gene Description: MEMO1 may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
UniGene ID: Mm.311874