mouse KDM6A shRNA silencing AAV

Cat. No: shAAV-257562

Availability: 4-5 weeks

Name: AAV-m-KDM6A-shRNA

This is an AAV expressing shRNA for silencing of Mouse Kdm6a.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Kdm6a
Gene Name: lysine (K)-specific demethylase 6A
Gene ID: 22289
Gene Synonyms: Utx
ORF Size: 4275 bp
RefSeq#: NM_009483
Gene Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
UniGene ID: Mm.257498