human SRGN shRNA silencing AAV

Cat. No: shAAV-224330

Availability: 4-5 weeks

Name: AAV-h-SRGN-shRNA

This is an AAV expressing shRNA for silencing of Human SRGN.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SRGN
Gene Name: serglycin
Gene ID: 5552
Gene Synonyms: PPG; PRG; PRG1
ORF Size: 477 bp
RefSeq#: NM_002727
Gene Description: SRGN encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
UniGene ID: Hs.1908
HGNC ID: HGNC:9361