human PHGDH shRNA silencing AAV

Cat. No: shAAV-218825

Availability: 4-5 weeks

Name: AAV-h-PHGDH-shRNA

This is an AAV expressing shRNA for silencing of Human PHGDH.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PHGDH
Gene Name: phosphoglycerate dehydrogenase
Gene ID: 26227
Gene Synonyms: 3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA
ORF Size: 1602 bp
RefSeq#: NM_006623
Gene Description: PHGDH encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.
UniGene ID: Hs.487296
HGNC ID: HGNC:8923