mouse NEK6 shRNA silencing AAV

Cat. No: shAAV-265654

Availability: 4-5 weeks

Name: AAV-m-NEK6-shRNA

This is an AAV expressing shRNA for silencing of Mouse Nek6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Nek6
Gene Name: NIMA (never in mitosis gene a)-related expressed kinase 6
Gene ID: 59126
Gene Synonyms: 1300007C09Rik
ORF Size: 942 bp
RefSeq#: NM_021606
Gene Description: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.
UniGene ID: Mm.143818