mouse KDM2B shRNA silencing AAV

Cat. No: shAAV-262760

Availability: 4-5 weeks

Name: AAV-m-KDM2B-shRNA

This is an AAV expressing shRNA for silencing of Mouse KDM2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: KDM2B
Gene Name: lysine (K)-specific demethylase 2B
Gene ID: 30841
Gene Synonyms: Cxxc2; Fbl10; Fbxl10; Jhdm1b; PCCX2
ORF Size: 2331 bp
RefSeq#: NM_001003953
Gene Description: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
UniGene ID: Mm.86406