human OGG1 shRNA silencing AAV

Cat. No: shAAV-217386

Availability: 4-5 weeks

Name: AAV-h-OGG1-shRNA

This is an AAV expressing shRNA for silencing of Human OGG1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OGG1
Gene Name: 8-oxoguanine DNA glycosylase
Gene ID: 4968
Gene Synonyms: HMMH; HOGG1; MUTM; OGH1
ORF Size: 1038 bp
RefSeq#: NM_002542
Gene Description: OGG1 encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
UniGene ID: Hs.380271
HGNC ID: HGNC:8125