human PLAUR shRNA silencing AAV

Cat. No: shAAV-219111

Availability: 4-5 weeks

Name: AAV-h-PLAUR-shRNA

This is an AAV expressing shRNA for silencing of Human PLAUR.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PLAUR
Gene Name: plasminogen activator, urokinase receptor
Gene ID: 5329
Gene Synonyms: CD87; U-PAR; UPAR; URKR
ORF Size: 1008 bp
RefSeq#: NM_002659
Gene Description: PLAUR encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
UniGene ID: Hs.466871
HGNC ID: HGNC:9053