human TPP1 shRNA silencing AAV

Cat. No: shAAV-226283

Availability: 4-5 weeks

Name: AAV-h-TPP1-shRNA

This is an AAV expressing shRNA for silencing of Human TPP1.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TPP1
Gene Name: tripeptidyl peptidase 1
Gene ID: 1200
Gene Synonyms: CLN2; GIG1; LPIC; SCAR7; TPP-1
ORF Size: 1692 bp
RefSeq#: NM_000391
Gene Description: TPP1 encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
UniGene ID: Hs.523454
HGNC ID: HGNC:2073