human DUSP11 shRNA silencing AAV

Cat. No: shAAV-207410

Availability: 4-5 weeks

Name: AAV-h-DUSP11-shRNA

This is an AAV expressing shRNA for silencing of Human DUSP11.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DUSP11
Gene Name: dual specificity phosphatase 11
Gene ID: 8446
Gene Synonyms: PIR1
ORF Size: 993 bp
RefSeq#: NM_003584
Gene Description: DUSP11 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
UniGene ID: Hs.14611
HGNC ID: HGNC:3066