human HERC5 shRNA silencing AAV

Cat. No: shAAV-210954

Availability: 4-5 weeks

Name: AAV-h-HERC5-shRNA

This is an AAV expressing shRNA for silencing of Human HERC5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HERC5
Gene Name: HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene ID: 51191
Gene Synonyms: CEB1; CEBP1
ORF Size: 3075 bp
RefSeq#: NM_016323
Gene Description: HERC5 is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
UniGene ID: Hs.26663
HGNC ID: HGNC:24368