human RFX5 shRNA silencing Adenovirus

Cat. No: shADV-221073

Availability: 3-5 weeks

Name: Ad-h-RFX5-shRNA

This is an Adenovirus expressing shRNA for silencing of Human RFX5.

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Species: Human
Gene Symbol: RFX5
Gene Name: regulatory factor X5
Gene ID: 5993
ORF Size: 1851 bp
RefSeq#: NM_000449
Gene Description: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
UniGene ID: Hs.632472
HGNC ID: HGNC:9986