mouse APLP1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Aplp1

Gene Name

amyloid beta (A4) precursor-like protein 1

Gene ID

11803

ORF Size

1965 bp

RefSeq#

NM_007467

Gene Description

APLP1 may play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I|Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (By similarity).

UniGene ID

Mm.2381