human KLF11 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

KLF11

Gene Name

Kruppel like factor 11

Gene ID

8462

Gene Synonyms

FKLF; FKLF1; MODY7; TIEG2; Tieg3

ORF Size

1539 bp

RefSeq#

NM_003597

Gene Description

KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.

UniGene ID

Hs.12229

HGNC ID

HGNC:11811