human KALRN shRNA silencing Adenovirus

Product Info

Knockdown

>60% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

KALRN

Gene Name

kalirin, RhoGEF kinase

Gene ID

8997

Gene Synonyms

ARHGEF24; CHD5; CHDS5; DUET; DUO; HAPIP; TRAD

ORF Size

4992 bp

RefSeq#

NM_007064

Gene Description

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

UniGene ID

Hs.8004

HGNC ID

HGNC:4814