human ARFGAP3 shRNA silencing AAV

Cat. No: shAAV-218109

Availability: 4-5 weeks

Name: AAV-h-ARFGAP3-shRNA

This is an AAV expressing shRNA for silencing of Human ARFGAP3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ARFGAP3
Gene Name: ADP ribosylation factor GTPase activating protein 3
Gene ID: 26286
Gene Synonyms: ARFGAP1
ORF Size: 1551 bp
RefSeq#: NM_014570
Gene Description: ARFGAP3 is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
UniGene ID: Hs.162877
HGNC ID: HGNC:661