human GTF2A2 shRNA silencing Adenovirus

Cat. No: shADV-210630

Availability: 3-5 weeks

Name: Ad-h-GTF2A2-shRNA

This is an Adenovirus expressing shRNA for silencing of Human GTF2A2.

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Species: Human
Gene Symbol: GTF2A2
Gene Name: general transcription factor IIA subunit 2
Gene ID: 2958
Gene Synonyms: HsT18745; T18745; TF2A2; TFIIA; TFIIA-12; TFIIA-gamma; TFIIAS
ORF Size: 330 bp
RefSeq#: NM_004492
Gene Description: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 (PubMed 7724559)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.512934
HGNC ID: HGNC:4647