human TLE1 shRNA silencing Adenovirus

Name
Ad-h-TLE1-shRNA

Cat No
shADV-225562

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human TLE1.

shADV-225562

Ad-h-TLE1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TLE1 (transducin like enhancer of split 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

E(Sp1) homolog; enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer protein 1

Description (eCommerce)

transducin-like enhancer protein 1 (TLE1) is a transcriptional corepressor that binds to a number of transcription factors. TLE1 Inhibits NF-kappa-B-regulated gene expression and inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q04724].

Gene ID

7088

Gene Name (eCommerce)

transducin like enhancer of split 1

Gene Name (Vector)

transducin like enhancer of split 1

Gene Symbol

TLE1

HGNC ID

HGNC:11837

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2313

ORF Size (bp)

2313 bp

Protein Name (eCommerce)

Transducin-like enhancer protein 1

RefSeq ID

NM_005077

RefSeq Synonyms

NM_005077, NM_001303104, NM_001303103, BC015747, BC010100,

Research Areas

Cancer,Gene Expression,NF-kB Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

transducin-like enhancer protein 1 (TLE1) is a transcriptional corepressor that binds to a number of transcription factors. TLE1 Inhibits NF-kappa-B-regulated gene expression and inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q04724].

UniGene ID

Hs.689805

UniProt ID (eCommerce)

Q04724

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.