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human PHAX shRNA silencing AAV

Name 
AAV-h-PHAX-shRNA
Cat No 
shAAV-230998
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PHAX.

shAAV-230998
AAV-h-PHAX-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PHAX (phosphorylated adaptor for RNA export). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor (phosphorylation regulated); RNUXA
Description (eCommerce)
Phosphorylated adapter RNA export protein (PHAX) is a phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. PHAX also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). It is involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H814].
Gene ID
51808
Gene Name (eCommerce)
phosphorylated adaptor for RNA export
Gene Name (Vector)
phosphorylated adaptor for RNA export
Gene Symbol
PHAX
HGNC ID
HGNC:10241
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1185
ORF Size (bp)
1185 bp
Protein Name (eCommerce)
Phosphorylated adapter RNA export protein
RefSeq ID
NM_032177
RefSeq Synonyms
NM_032177, BC021161,
Research Areas
Gene Expression,Neurobiology,RNA Binding,RNA Processing,RNA Transport,Spliceosome,Transport
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,cell_biology
Species
human
Target Sentence
Phosphorylated adapter RNA export protein (PHAX) is a phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. PHAX also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). It is involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H814].
UniGene ID
Hs.719165
UniProt ID (eCommerce)
Q9H814

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.