rat SIGIRR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Sigirr.
shAAV-293981
AAV-r-SIGIRR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Sigirr (single Ig and TIR domain containing). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGD1306732
Description (Vector)
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Gene ID
309106
Gene Name (Vector)
single Ig and TIR domain containing
Gene Symbol
Sigirr
ORF Size (aa)
1230
ORF Size (bp)
1230 bp
RefSeq ID
NM_001024887
RefSeq Synonyms
NM_001024887, BC097488,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.