mouse SIGIRR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Sigirr.
shAAV-271983
AAV-m-SIGIRR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Sigirr (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI256711; TIR8
Description (Vector)
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Gene ID
24058
Gene Name (Vector)
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Gene Symbol
Sigirr
ORF Size (aa)
1164
ORF Size (bp)
1164 bp
RefSeq ID
NM_023059
RefSeq Synonyms
NM_023059, BC094069, BC010806,
Species
mouse
UniGene ID
Mm.38017
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.