Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human SCYE1 shRNA silencing AAV

Name 
AAV-h-SCYE1-shRNA
Cat No 
shAAV-222405
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human AIMP1.

shAAV-222405
AAV-h-SCYE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1; ARS-interacting multifunctional protein 1; EMAP2; EMAPII; endothelial monocyte-activating polypeptide 2; endothelial-monocyte activating polypeptide II; HLD3; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; p43; SCYE1; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Description (eCommerce)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cell [taken from NCBI Entrez Gene (Gene ID: 9255)].
Description (Vector)
AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
Gene ID
9255
Gene Name (eCommerce)
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Gene Name (Vector)
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Gene Symbol
AIMP1
HGNC ID
HGNC:10648
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
939
ORF Size (bp)
939 bp
Protein Name (eCommerce)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
RefSeq ID
NM_004757
RefSeq Synonyms
NM_004757, NM_001142416, NM_001142415, BC014051,
Research Areas
Angiogenesis,Apoptosis,Cardiovascular,Gene Expression,Golgi Apparatus,Immunology,Metabolism/Metabolic Process,Neurobiology,RNA Binding,Signal Transduction,Translational Control,tRNA Binding
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cell [taken from NCBI Entrez Gene (Gene ID: 9255)].
UniGene ID
Hs.591680
UniProt ID (eCommerce)
Q12904

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.