human FANCD2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FANCD2.
shAAV-208695
AAV-h-FANCD2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FANCD2 (Fanconi anemia complementation group D2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FA4; FACD; FAD; FAD2; FA-D2; FANCD; Fanconi anemia complementation group D2; Fanconi anemia group D2 protein; Protein FACD2
Description (eCommerce)
FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.
Description (Vector)
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
Gene ID
2177
Gene Name (eCommerce)
FA complementation group D2
Gene Name (Vector)
Fanconi anemia complementation group D2
Gene Symbol
FANCD2
HGNC ID
HGNC:3585
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4416
ORF Size (bp)
4416 bp
Protein Name (eCommerce)
Fanconi anemia group D2 protein
RefSeq ID
NM_033084
RefSeq Synonyms
NM_033084, NM_001319984, NM_001018115, BC156799, BC013582,
Research Areas
Cancer,Cell Cycle,DNA Damage/Repair,Fanconi anemia,Homologous Recombination,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.
UniGene ID
Hs.208388
UniProt ID (eCommerce)
Q9BXW9
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.