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mouse FANCD2 shRNA silencing AAV

Name 
AAV-m-FANCD2-shRNA
Cat No 
shAAV-259148
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Fancd2.

shAAV-259148
AAV-m-FANCD2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Fancd2 (Fanconi anemia, complementation group D2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2410150O07Rik; AU015151; BB137857; FA-D2; FA4; FACD; FAD; FANCD
Description (Vector)
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Gene ID
211651
Gene Name (Vector)
Fanconi anemia, complementation group D2
Gene Symbol
Fancd2
ORF Size (aa)
4353
ORF Size (bp)
4353 bp
RefSeq ID
NM_001033244
RefSeq Synonyms
NM_001347350, NM_001033244, BC139004,
Species
mouse
UniGene ID
Mm.160061

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.