mouse TFRC Over-expression AAV

Name 
AAV-m-TFRC
Cat No 
AAV-274094
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tfrc.

AAV-274094
AAV-m-TFRC

Ready-to-use AAV expressing Mouse Tfrc (transferrin receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2610028K12Rik; CD71; E430033M20Rik; Mtvr1; p90; TFR; TFR1; TR; Trfr
Description (Vector)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Gene ID
22042
Gene Name (Vector)
transferrin receptor
Gene Symbol
Tfrc
ORF Size (aa)
2292
ORF Size (bp)
2292 bp
RefSeq ID
NM_011638
RefSeq Synonyms
NM_011638, BC054522,
Species
mouse
UniGene ID
Mm.28683

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.