human TFRC shRNA silencing AAV

Name 
AAV-h-TFRC-shRNA
Cat No 
shAAV-225374
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TFRC.

shAAV-225374
AAV-h-TFRC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TFRC (transferrin receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD71; CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR
Description (eCommerce)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P02786].
Gene ID
7037
Gene Name (eCommerce)
transferrin receptor
Gene Name (Vector)
transferrin receptor
Gene Symbol
TFRC
HGNC ID
HGNC:11763
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
Protein Name (eCommerce)
Transferrin receptor protein 1
RefSeq ID
NM_003234
RefSeq Synonyms
NM_003234, NM_001313966, NM_001313965, NM_001128148, BC001188,
Research Areas
Aging,EGFR Signaling,Golgi Apparatus,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,Immunology,Mitochondrion,Signal Transduction,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P02786].
UniGene ID
Hs.529618
UniProt ID (eCommerce)
P02786

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.