mouse TCF7L2 Over-expression AAV

Name 
AAV-m-TCF7L2
Cat No 
AAV-273924
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tcf7l2.

AAV-273924
AAV-m-TCF7L2

Ready-to-use AAV expressing Mouse Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Tcf-4; Tcf4; TCF4B; TCF4E
Description (Vector)
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Gene ID
21416
Gene Name (Vector)
transcription factor 7 like 2, T cell specific, HMG box
Gene Symbol
Tcf7l2
ORF Size (aa)
1380
ORF Size (bp)
1380 bp
RefSeq ID
NM_009333
RefSeq Synonyms
NM_009333, NM_001331150, NM_001331149, NM_001331148, NM_001331147, NM_001331146, NM_001331145, NM_001331144, NM_001331143, NM_001331142, NM_001331141, NM_001331140, NM_001331139, NM_001331138, NM_001331137, NM_001331136, NM_001331135, NM_001142924, NM_001142923, NM_001142922, NM_001142921, NM_001142920, NM_001142919, NM_001142918, BC052022,
Species
mouse
UniGene ID
Mm.139815

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.