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mouse TCF7L2 shRNA silencing Adenovirus

Name 
Ad-m-TCF7L2-shRNA
Cat No 
shADV-273924
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Tcf7l2.

shADV-273924
Ad-m-TCF7L2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Tcf-4; Tcf4; TCF4B; TCF4E
Description (Vector)
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Gene ID
21416
Gene Name (Vector)
transcription factor 7 like 2, T cell specific, HMG box
Gene Symbol
Tcf7l2
ORF Size (aa)
1380
ORF Size (bp)
1380 bp
RefSeq ID
NM_009333
RefSeq Synonyms
NM_009333, NM_001331150, NM_001331149, NM_001331148, NM_001331147, NM_001331146, NM_001331145, NM_001331144, NM_001331143, NM_001331142, NM_001331141, NM_001331140, NM_001331139, NM_001331138, NM_001331137, NM_001331136, NM_001331135, NM_001142924, NM_001142923, NM_001142922, NM_001142921, NM_001142920, NM_001142919, NM_001142918, BC052022,
Species
mouse
UniGene ID
Mm.139815

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.