human TIRAP Over-expression AAV

Name 
AAV-h-TIRAP
Cat No 
AAV-225542
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TIRAP.

AAV-225542
AAV-h-TIRAP

Ready-to-use AAV expressing Human TIRAP (TIR domain containing adaptor protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BACTS1; Mal; MyD88-2; wyatt
Description (Vector)
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Gene ID
114609
Gene Name (Vector)
TIR domain containing adaptor protein
Gene Symbol
TIRAP
HGNC ID
HGNC:17192
ORF Size (aa)
771
RefSeq ID
NM_148910
RefSeq Synonyms
NM_148910, NM_001318777, NM_001318776, NM_001039661, BC032474,
Species
human
UniGene ID
Hs.537126

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.