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human TIRAP shRNA silencing Adenovirus

Name 
Ad-h-TIRAP-shRNA
Cat No 
shADV-225542
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TIRAP.

shADV-225542
Ad-h-TIRAP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TIRAP (TIR domain containing adaptor protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BACTS1; Mal; MyD88-2; wyatt
Description (Vector)
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Gene ID
114609
Gene Name (Vector)
TIR domain containing adaptor protein
Gene Symbol
TIRAP
HGNC ID
HGNC:17192
ORF Size (aa)
771
RefSeq ID
NM_148910
RefSeq Synonyms
NM_148910, NM_001318777, NM_001318776, NM_001039661, BC032474,
Species
human
UniGene ID
Hs.537126

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.