mouse TIRAP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tirap.
shAAV-274243
AAV-m-TIRAP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA407980; C130027E04Rik; Mal; Tlr4ap; Wyatt
Description (Vector)
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Gene ID
117149
Gene Name (Vector)
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Gene Symbol
Tirap
ORF Size (aa)
726
ORF Size (bp)
726 bp
RefSeq ID
NM_054096
RefSeq Synonyms
NM_054096, NM_001177847, NM_001177846, NM_001177845, BC005584,
Species
mouse
UniGene ID
Mm.392992
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.