human TMC6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TMC6.
shAAV-225656
AAV-h-TMC6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TMC6 (transmembrane channel like 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EV1; EVER1; EVIN1; LAK-4P
Description (Vector)
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.
Gene ID
11322
Gene Name (Vector)
transmembrane channel like 6
Gene Symbol
TMC6
HGNC ID
HGNC:18021
ORF Size (aa)
1335
ORF Size (bp)
1335 bp
RefSeq ID
NM_007267
RefSeq Synonyms
NM_007267, NM_001321185, NM_001127198, BC035648, BC023597, BC007766,
Species
human
UniGene ID
Hs.632227
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.