human TJP3 Over-expression AAV

Name 
AAV-h-TJP3
Cat No 
AAV-225547
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TJP3.

AAV-225547
AAV-h-TJP3

Ready-to-use AAV expressing Human TJP3 (tight junction protein 3 (zona occludens 3)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Tight junction protein 3; tight junction protein 3 (zona occludens 3); tight junction protein ZO-3; ZO3; ZO-3; zona occludens protein 3; zonula occludens protein 3
Description (eCommerce)
Tight junction protein 3 (TJP3) is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis [taken from NCBI Entrez Gene (Gene ID: 27134)].
Description (Vector)
TJP3 is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.
Gene ID
27134
Gene Name (eCommerce)
tight junction protein 3
Gene Name (Vector)
tight junction protein 3 (zona occludens 3)
Gene Symbol
TJP3
HGNC ID
HGNC:11829
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2817
ORF Size (bp)
2817 bp
Protein Name (eCommerce)
Tight junction protein ZO-3
RefSeq ID
NM_014428
RefSeq Synonyms
NM_014428, NM_001267561, NM_001267560, BC108906,
Research Areas
Cell Biology,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Tight junction protein 3 (TJP3) is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis [taken from NCBI Entrez Gene (Gene ID: 27134)].
UniGene ID
Hs.25527
UniProt ID (eCommerce)
O95049

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.