human SCYE1 Over-expression AAV

Name 
AAV-h-SCYE1
Cat No 
AAV-222405
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human AIMP1.

AAV-222405
AAV-h-SCYE1

Ready-to-use AAV expressing Human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1; ARS-interacting multifunctional protein 1; EMAP2; EMAPII; endothelial monocyte-activating polypeptide 2; endothelial-monocyte activating polypeptide II; HLD3; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; p43; SCYE1; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Description (eCommerce)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cell [taken from NCBI Entrez Gene (Gene ID: 9255)].
Description (Vector)
AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
Gene ID
9255
Gene Name (eCommerce)
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Gene Name (Vector)
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Gene Symbol
AIMP1
HGNC ID
HGNC:10648
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
939
ORF Size (bp)
939 bp
Protein Name (eCommerce)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
RefSeq ID
NM_004757
RefSeq Synonyms
NM_004757, NM_001142416, NM_001142415, BC014051,
Research Areas
Angiogenesis,Apoptosis,Cardiovascular,Gene Expression,Golgi Apparatus,Immunology,Metabolism/Metabolic Process,Neurobiology,RNA Binding,Signal Transduction,Translational Control,tRNA Binding
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cell [taken from NCBI Entrez Gene (Gene ID: 9255)].
UniGene ID
Hs.591680
UniProt ID (eCommerce)
Q12904

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.