human SECISBP2 Over-expression AAV

Name 
AAV-h-SECISBP2
Cat No 
AAV-222510
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SECISBP2.

AAV-222510
AAV-h-SECISBP2

Ready-to-use AAV expressing Human SECISBP2 (SECIS binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SBP2; Sec insertion sequence-binding protein 2; SECIS-binding protein 2; selenocysteine insertion sequence-binding protein 2
Description (eCommerce)
SECIS-binding protein 2 (SBP2) binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96T21].
Description (Vector)
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
Gene ID
79048
Gene Name (eCommerce)
SECIS binding protein 2
Gene Name (Vector)
SECIS binding protein 2
Gene Symbol
SECISBP2
HGNC ID
HGNC:30972
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2565
ORF Size (bp)
2565 bp
Protein Name (eCommerce)
Selenocysteine insertion sequence-binding protein 2
RefSeq ID
NM_024077
RefSeq Synonyms
NM_024077, NM_001282690, NM_001282689, NM_001282688, BC036109, BC001189,
Research Areas
Mitochondrion,mRNA Binding,RNA Binding,Translational Control
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
SECIS-binding protein 2 (SBP2) binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96T21].
UniGene ID
Hs.59804
UniProt ID (eCommerce)
Q96T21

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.