human SECISBP2 shRNA silencing AAV

Name 
AAV-h-SECISBP2-shRNA
Cat No 
shAAV-222510
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SECISBP2.

shAAV-222510
AAV-h-SECISBP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SECISBP2 (SECIS binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SBP2; Sec insertion sequence-binding protein 2; SECIS-binding protein 2; selenocysteine insertion sequence-binding protein 2
Description (eCommerce)
SECIS-binding protein 2 (SBP2) binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96T21].
Description (Vector)
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
Gene ID
79048
Gene Name (eCommerce)
SECIS binding protein 2
Gene Name (Vector)
SECIS binding protein 2
Gene Symbol
SECISBP2
HGNC ID
HGNC:30972
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2565
ORF Size (bp)
2565 bp
Protein Name (eCommerce)
Selenocysteine insertion sequence-binding protein 2
RefSeq ID
NM_024077
RefSeq Synonyms
NM_024077, NM_001282690, NM_001282689, NM_001282688, BC036109, BC001189,
Research Areas
Mitochondrion,mRNA Binding,RNA Binding,Translational Control
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
SECIS-binding protein 2 (SBP2) binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96T21].
UniGene ID
Hs.59804
UniProt ID (eCommerce)
Q96T21

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.