human LGI1 Over-expression AAV

Name
AAV-h-LGI1

Cat No
AAV-213868

Availability
4-5 weeks

This is an AAV expressing Human LGI1.

AAV-213868

AAV-h-LGI1

Ready-to-use AAV expressing Human LGI1 (leucine rich glioma inactivated 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099

Description (Vector)

LGI1 is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. LGI1 is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy.

Gene ID

9211

Gene Name (Vector)

leucine rich glioma inactivated 1

Gene Symbol

LGI1

HGNC ID

HGNC:6572

ORF Size (aa)

1674

ORF Size (bp)

1674 bp

RefSeq ID

NM_005097

RefSeq Synonyms

NM_005097, NM_001308276, NM_001308275, BC022500,

Species

human

UniGene ID

Hs.533670

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.