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human CBX4 Over-expression AAV

Name 
AAV-h-CBX4
Cat No 
AAV-204199
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CBX4.

AAV-204199
AAV-h-CBX4

Ready-to-use AAV expressing Human CBX4 (chromobox 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; polycomb 2 homolog
Description (eCommerce)
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
Gene ID
8535
Gene Name (eCommerce)
chromobox 4
Gene Name (Vector)
chromobox 4
Gene Symbol
CBX4
HGNC ID
HGNC:1554
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
873
ORF Size (bp)
873 bp
Protein Name (eCommerce)
E3 SUMO-protein ligase CBX4
RefSeq ID
NM_003655
RefSeq Synonyms
NM_003655, BC014967,
Research Areas
Apoptosis,Chromatin Remodeling,Complexome,Golgi Apparatus,Polycomb Proteins,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
UniGene ID
Hs.714363
UniProt ID (eCommerce)
O00257

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.