human CBX4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CBX4.
shADV-204199
Ad-h-CBX4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CBX4 (chromobox 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; polycomb 2 homolog
Description (eCommerce)
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
Gene ID
8535
Gene Name (eCommerce)
chromobox 4
Gene Name (Vector)
chromobox 4
Gene Symbol
CBX4
HGNC ID
HGNC:1554
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
873
ORF Size (bp)
873 bp
Protein Name (eCommerce)
E3 SUMO-protein ligase CBX4
RefSeq ID
NM_003655
RefSeq Synonyms
NM_003655, BC014967,
Research Areas
Apoptosis,Chromatin Remodeling,Complexome,Golgi Apparatus,Polycomb Proteins,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
UniGene ID
Hs.714363
UniProt ID (eCommerce)
O00257
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.