human Synapsin 1 promoter driven saCas9/CRISPR AAV AAV
The main issue with Cas9 from Streptococcus pyogenes SF370 (SpCas9) is that this gene is too big to be packaged into AAV for most promoters, and there's no extra room for a sgRNA with the spCas9 in same AAV. A small Cas9 from Staphylococcus aureus subsp. aureus (SaCas9) with high efficiency for cleaving mammalian endogenous DNA becomes the ideal solution to package into AAV for effective gene modification in vivo.
This is an AAV-DJ (a synthetic serotype made from 8 wild type AAV including AAV2, 4, 5, 8, 9) expressing spCas9 nuclease under a neuronal specific human synapsin 1 promoter. This AAV-hSYN-saCas9 can be package into other AAV serotypes upon request.
We also offer custom AAV production service to package AAV-hSYN-saCas9 with your sgRNA in the same AAV virus. Please contact us for detail.
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- Viral Backbone
- Recombinant AAV
- AAV Serotype
- hSYN1 ()
- Storage Buffer
- PBS/5% Glycerol
- 50 ul
- 1x10^13 GC/ml
- Gene Symbol