v-fos FBJ murine osteosarcoma viral oncogene homolog Adenovirus

Name 
Ad-FOS
Cat No 
1536
Availability
Immediate
Categories
Adenovirus, Over-Expression

The activator protein-1 (AP-1) transcription factor consists of either Jun homodimers or Fos/Jun heterodimeric complexes, which bind the palindromic TRE sequence TGA(C/G)TCA. The Jun family includes c-Jun, Jun B and Jun D, while the Fos gene family members include c-Fos, Fos B, Fra-1 and Fra-2. In addition, certain ATF/CREB proteins form leucine zipper dimers with Fos and Jun, which exhibit different specificities for AP-1 and CRE DNA motifs. AP-1 transcription factor components are subject to regulation by both phosphorylation and by chemical oxidation of specific cysteine residues mapping within the DNA binding domains of Fos and Jun. Oxidation is reversible by a cellular redox/DNA repair protein designated Ref-1 (redox factor 1). JAB1 (Jun-activation domain-binding protein 1) potentiates transcription by either c-Jun or Jun D.

1536
Ad-FOS

Ready-to-use v-fos FBJ murine osteosarcoma viral oncogene homolog Adenovirus. Ad-FOS, v-fos FBJ murine osteosarcoma viral oncogene homolog, FOS, c-Fos adenovirus 1536

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
AP-1; C-FOS; p55
Description (Vector)
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Gene ID
2353
Gene Name (Vector)
Fos proto-oncogene, AP-1 transcription factor subunit
Gene Symbol
FOS
HGNC ID
HGNC:3796
ORF Size (aa)
1143
RefSeq ID
NM_005252
RefSeq Synonyms
NM_005252, BC004490,
Species
human
UniGene ID
Hs.707896

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.