mouse FOS shRNA silencing AAV

Name
AAV-m-FOS-shRNA

Cat No
shAAV-259549

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Fos.

shAAV-259549

AAV-m-FOS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Fos (FBJ osteosarcoma oncogene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

c-fos; cFos; D12Rfj1

Description (Vector)

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Gene ID

14281

Gene Name (Vector)

FBJ osteosarcoma oncogene

Gene Symbol

Fos

ORF Size (aa)

1143

ORF Size (bp)

1143 bp

RefSeq ID

NM_010234

RefSeq Synonyms

NM_010234, BC029814,

Species

mouse

UniGene ID

Mm.246513

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.