CASP8 and FADD-like apoptosis regulator Adenovirus

Name 
Ad-FLIP
Cat No 
1525
Availability
Immediate

FLIP (FLICE inhibitory protein), also designated CLARP, Casper, I-FLICE, FLAME-1 and MRIT, is expressed as both long (FLIPL) and short (FLIPS) isoforms and is involved in the regulation of apoptosis. The short form of FLIP contains two death effector domains homologous to the death effector domain of the FAS-associating protein FADD. The long form of FLIP contains an additional caspase-like domain, but lacks a catalytic active site and the residues that form the substrate binding pocket in most caspases.

1525
Ad-FLIP

Ready-to-use CASP8 and FADD-like apoptosis regulator Adenovirus. Ad-FLIP, CASP8 and FADD-like apoptosis regulator, CASH, FLIP, MRIT, CFLAR, CLARP, FLAME, CASPER, FLAME-1, I-FLICE, USURPIN, CASP8AP1 adenovirus 1525

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
Description (Vector)
CFLAR is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
Gene ID
8837
Gene Name (Vector)
CASP8 and FADD like apoptosis regulator
Gene Symbol
CFLAR
HGNC ID
HGNC:1876
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
RefSeq ID
NM_003879
RefSeq Synonyms
NM_003879, NM_001308043, NM_001308042, NM_001202519, NM_001202518, NM_001202517, NM_001202516, NM_001202515, NM_001127184, NM_001127183, BC001602,
Species
human
UniGene ID
Hs.390736

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.