Rb Adenovirus
The retinoblastoma susceptibility protein Rb is a 110 kDa phosphorylated protein. Like p53, Rb p110 is an anti-oncogene that is subject to inactivation by either mutation or by binding to certain DNA tumor virus-encoded proteins. Rb binds to and regulates transcription factors involved in cell cycle regulation, including the E2F family. Two Rb related proteins, p107 and p130, also function to regulate specific members of the E2F transcription factor family. Binding and inactivation of E2F proteins by Rb is regulated by cyclin dependent kinase-mediated phosphorylation
1043
Ad-CMV-Rb
Ready-to-use Rb Adenovirus. Rb adenovirus 1043
Original price was: $475.00.$403.75Current price is: $403.75.
Related Citations
- Involvement of the STAT5-CyclinD/CDK4-pRb pathway in beta cell proliferation stimulated by prolactin during pregnancy. X Zhao, etc, (2018), American Journal of Physiology-Endocrinology and Metabolism
- Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action. Erica P. Cai, etc, (2014), Diabetologia
- Rb Depletion Results In Deregulation Of E-Cadherin And Induction Of Cellular Phenotypic Changes That Are Characteristic Of The Epithelial-To-Mesenchymal Transition. Arima, Y., etc., (2008), Cancer Research
- Proto-Oncogene Fbi-1 (Pokemon/Zbtb7a) Represses Transcription Of The Tumor Suppressor Rb Gene Via Binding Competition With Sp1 And Recruitment Of Co-Repressors. Jeon BN, etc, (2008), J. Biol. Chem
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.