mouse CFLAR shRNA silencing AAV

Name
AAV-m-CFLAR-shRNA

Cat No
shAAV-255341

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Cflar.

shAAV-255341

AAV-m-CFLAR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cflar (CASP8 and FADD-like apoptosis regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT

Description (Vector)

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Gene ID

12633

Gene Name (Vector)

CASP8 and FADD-like apoptosis regulator

Gene Symbol

Cflar

ORF Size (aa)

1446

ORF Size (bp)

1446 bp

RefSeq ID

NM_009805

RefSeq Synonyms

NM_207653, NM_009805, NM_001293805, NM_001293804, NM_001289704, BC029223,

Species

mouse

UniGene ID

Mm.336848

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.