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human BRD2 Over-expression AAV

Name 
AAV-h-BRD2
Cat No 
AAV-202256
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BRD2.

AAV-202256
AAV-h-BRD2

Ready-to-use AAV expressing Human BRD2 (bromodomain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BRD2 intronic transcript 1; BRD2-IT1; bromodomain-containing protein 2; D6S113E; female sterile homeotic-related gene 1; FSH; FSRG1; NAT; O27.1.1; really interesting new gene 3 protein; RING3; RNF3
Description (eCommerce)
BRD2 (bromodomain-containing 2) is a nuclear mitogen-activated kinase that plays a role in transcription of cell-cycle-regulated genes by functioning as an adapter protein that recruits E2F and chromatin remodeling factors to E2F response elements.
Description (Vector)
BRD2 encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. BRD2 has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
Gene ID
6046
Gene Name (eCommerce)
bromodomain containing 2
Gene Name (Vector)
bromodomain containing 2
Gene Symbol
BRD2
HGNC ID
HGNC:1103
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2511
ORF Size (bp)
2511 bp
Protein Name (eCommerce)
Bromodomain-containing protein 2
RefSeq ID
NM_005104
RefSeq Synonyms
NM_005104, NM_001291986, NM_001199456, NM_001199455, NM_001113182, BC063840,
Research Areas
Chromatin Remodeling,Kinase/Phosphatase,Spermatogenesis,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
BRD2 (bromodomain-containing 2) is a nuclear mitogen-activated kinase that plays a role in transcription of cell-cycle-regulated genes by functioning as an adapter protein that recruits E2F and chromatin remodeling factors to E2F response elements.
UniGene ID
Hs.75243
UniProt ID (eCommerce)
P25440

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.